熱痛定量感官測試儀-疼痛感覺測試設備

新型定量感官測試儀

是一個能夠準確和可復制的接觸性冷誘發電位的刺激器

準確·高效·MRI兼容

產品簡介

所有探頭都有多個獨立區域，都可以制造成兼容 MRI 的版本

部分出版物參考

1.      De Keyser R., van den Broeke E., Courtin A., Dufour A., Mouraux A. (2018). Event-related brain potentials elicited by high-speed cooling of the skin: A robust and non-painful method to assess the spinothalamic system in humans. Clinical Neurophysiology. 129(5), 1011-1019.

2.      Lenoir C., Algoet M. & Mouraux A. (2018). Deep continuous theta burst stimulation of the opercula-insular cortex selectively affects Adelta fibre heat pain. The Journal of Physiology. 596(19), 4767-4787.

3.      Mulders D., de Bodt C., Lejeune N., Courtin A., Liberati G., Verleysen M., Mouraux A. (2020). Dynamics of perception and EEG signals triggered by tonic warm and cool stimulation. Plos One, 15(4).

4.      van Neerven S.G.A. and Mouraux A. (2020). Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber-mediated heat sensitivity. Frontiers in Pharmacology. 11, 1-15

5.      Leone C., Di Lionardo A., Diotallevi G., Mollico C, Di Pietro G., Di Stephano G., La Cesa S., Cruccu G., Truini A. (2020). Conduction velocity of the cold spinal pathway in healthy humans. European Journal of Pain. Online ahead of print doi: 10.1002/ejp.1640.

6.      Liberati G., Mulders D., Algoed M., van den Broeke E., Ferrao Santos S., Géraldo Ribeiro Vaz J., Raftopoulos C., Mouraux A. (2020). Insular response to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG. Scientific Reports. 10:22319, 1-14.

7.      Courtin A. & Mouraux A. (2021). Combining Topical Agonists With the Recording of Event-Related Brain Potentials to Probe the Functional Involvement of TRPM8, TRPA1 and TRPV1 in Heat and Cold Transduction in the Human Skin. The Journal of Pain. Epub, 1-18.

8.      De Schoenmacker I., Archibald J., Kramer J.L.K. & Hubli M. (2022). Improved acquisition of contact heat evoked potentials with increased heating ramp. Scientific Reports, 12, 925.

9.      Fabig S.C, Kersebaum D., Lassen J., Sendel Manon, Jendral S., Muntan A., Baron R. & Hüllemann P. (2021). A modality-specific somatosensory evoked potential test protocol for clinical evaluation: A feasibility study. Clinical Neurophysiology. 132, 3104-3115.

臨床應用

Leone C., Dufour A., Di Stefano G., Fasolino A., Di Lionardo A., La Cesa S., Galosi E., Valeriani M.,Nolano M., Cruccu G. Truini A. (2019). Cooling the skin for assessing small-fibre function. Pain. 160(9), 1967-1975

采用自適應階梯法的高靈敏度QST

1.      Lithfous S., Després O, Pebayle T. & Dufour A. (2019). Modification of descending analgesia in aging: critical role of the prefrontal cortex.Clinical Journal of Pain. 35(1), 23-30.

2.      Després O, Lithfous S, Pebayle T. Casadio C. & Dufour A. (2019). Effects of thermosensory aging well demonstrated by cold stimulation with high temporal resolution.Muscle Nerve. 60(2)., 141-146.

3.      Lithfous S., Després O., Pebayle T., Casadio C. & Dufour A. (2020). Accurate determination of the cold detection threshold with high-speed cooling of the skin. Pain Medicine. online ahead of print.

模擬皮膚中的熱擴散

Dufour A., Després O, Pebayle T. & Lithfous S. (2020). Thermal sensitivity in humans at the depth of thermal receptor endings beneath the skin: validation of a heat transfer model of the skin using high-temporal resolution stimuli. European Journal of Applied Physiology. 120, 1509-1518.

動物研究

Gieré C., Melchior M., Dufour A., Poisbeau P. (2021).  Spinal integration of hot and cold nociceptive stimuli by wide dynamic range neurons in anesthetized adult rats. Pain Reports. Epub.